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. 2021 Jan 12;13(2):263. doi: 10.3390/cancers13020263

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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EO-Derived Factors Reduce Osteoclastogenesis. EO cells secrete soluble RANKL, which binds to the RANK receptor on osteoclast progenitor cells to initiate osteoclast differentiation. We found that EOs have decreased expression of osteoclastogenic factors OPG soluble protein and TNFα soluble protein. When determining the affect EO cells have on osteoclastogenesis, we found that osteoclasts exposed to EO-derived factors or produced in the presence of EO cells were less in number and smaller in size. When examining osteoclast fusion, we found that osteoclasts exposed to EO-derived factors have decreased expression of osteoclast-fusion protein DC-STAMP. Furthermore, osteoclasts produced in the presence of EO cells have decreased resorptive activity. Overall, the presence of EO cells decreases osteoclast formation and resorption, reducing osteoclastogenesis.