Table 1.

Biomarkers on Chromosomes associated with LOH.

Chromosome Associated with LOH	Gene Name	LOH Position	Predictive Biomarker	Reference
1p	N/A	1p36	Significantly associated with prognostic markers of aggressive neuroblastoma when patients are diagnosed	[61,62,63,64]
3p	FRA3B	3p13–3p21	Predicted early event in the genesis of smoking-related cancers.	[65,66]
	CACNA2D3	3p21	Associated with poor clinical outcome in esophageal cancer.	[67,68]
	VHL	3p25	Predictive biomarker for clinical outcome in clear-cell renal-cell carcinoma (ccRCC) patients.	[69]
6q	HLA	6p21	Leads to a poor response to immune checkpoint inhibitors.	[70]
			Predictive biomarker for patients with synovial sarcoma and is prognostic of poor clinical outcome.	[71]
	FABP7	6q22	Correlated with survival in patients with glioblastoma.	[72]
			A potential diagnostic biomarker of early-stage melanoma systemic spreading in blood.	[73]
9q	N/A	9p13	Significantly associated with poorer prognosis of glioma patients.	[74]
10q	PTEN	10q23	Functionally related to the development of breast cancer, associated with poor prognosis	[75]
11q	NELL1	11p15	An association between LOH at 11p15.5 and poor survival in 180 lung cancer patients.	[76]
16q	CD19	16p11	Irreversible loss of heterozygosity in CD19 could be used as a biomarker for an outcome prediction after the CAR T cells therapy CTL019.	[77]
17q	TP53	17p13	One of the most frequent genetic alterations leading to human cancers.	[78,79]
	BRCA1	17q21	A germline LOH on BRCA1 confront an 85% lifetime risk of breast cancer and a greatly elevated risk of ovarian cancer	[80]
18q	DPC4 (SMAD4)	18q21	Assist in predicting the clinical outcome after therapies in colorectal cancer (CRC) patients.	[81,82]