Table 2.
The number of hepatic GST-P-positive foci and colonic ACF of rats initiated with diethylnitrosamine and 1,2-dimethylhydrazine.
| Treatment | Preneoplastic Lesions | |||
|---|---|---|---|---|
| Liver | Colon | |||
| No. of GST-P+ foci/cm2 | Area of GST-P+ Foci (mm2/cm2) | Aberrant Crypt/Rat | Aberrant Crypt/Focus |
|
| NSS | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| NSS + PRHE 500 mg kg−1 BW | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| DEN + DMH | 17.45 ± 3.97 * | 1.84 ± 0.74 * | 169.56 ± 70.97 * | 4.45 ± 1.00 * |
| DEN + DMH + PRHE 500 mg kg−1 BW | 11.06 ± 4.89 ** | 1.37 ± 0.81 | 226.43 ± 112.61 | 4.68 ± 0.55 |
Values are expressed as mean ± SD. DEN: diethylnitrosamine 100 mg kg−1 BW, i.p. DMH: 1,2-dimethylhydrazine 40 mg kg−1 BW, s.c. NSS: normal saline solution 4 mL kg−1 BW. PRHE: purple rice husk extract. * Significantly different from negative control group, p < 0.05. ** Significantly different from positive control group, p < 0.05.