Figure 3.

Skin phenotype score, body weight and ratio of spleen to body weight. (A) Erythema, scaling, and thickness of the back skin were scored independently daily from Day 0 to Day10 (Expt. 2) on a scale from 0 to 4, and the cumulative score for erythema, scaling, and thickness over time was determined daily on a scale from 0–12. (B) The body weight (Day 0–10) and (C) ratio of spleen to body weight (Day 10) were also determined. Two independent animal experiments using different batches of exosome preparations were performed. The scores from the two independent studies were combined. Scoring (erythema, scaling, thickness, and cumulative score), body weights and ratio of spleen to body weight were analyzed using Student’s t-test. p values < 0.05 were considered as statistically significant.