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. 2021 Jan 13;10(1):146. doi: 10.3390/cells10010146

Figure 1.

Figure 1

Exercise-induced maximal mitochondrial respiration is dependent on β2-adrenergic receptor (β2-AR) signaling. Experimental design for aerobic exercise under β2-AR blockade with ICI 118,551 (a), basal mitochondrial OCR (oxygen consumption ratio) (b), maximal mitochondrial OCR induced by ADP (c), ATP-independent OCR measured in the presence of oligomycin (d), and the respiratory control ratio (e) in permeabilized fiber bundles of tibialis anterior muscle isolated from exercised mice (single bout in a treadmill—80% of Vmax for 1 h, 5° inclination), and/or under β2-AR receptor blockade with ICI 118,551 (single dose—10 mg/kg, i.p., 30 min prior to exercise). Data are presented as mean ± SE. * p < 0.05 vs. control and ** p < 0.05 vs. AE. n = 5/group.