Figure 2.

Skeletal muscle mitochondrial morphology is modulated by aerobic exercise, partially mediated by β₂-ARs. Mitochondrial area (a), perimeter (b), elongation (c), mitochondria number per area (d), and electron microscopic representative images (e) of tibialis anterior muscle from exercised mice (single bout in a treadmill—80% of Vmax for 1 h, 5° inclination), with or without β₂-AR blockade with ICI 118,551 (single dose—10 mg/kg, i.p., 30 min prior exercise). Data are presented as mean ± SE. * p < 0.05 vs. control and ** p < 0.05 vs. AE. n = 5/group.