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Schematic representation of T cell receptor (TCR) engineered T cells and chimeric antigen receptors (CAR) engineered T cells in hepatocellular carcinoma. Main tumor associated antigens (TAA) are represented in green. Abbreviations: AFP = alpha-fetoprotein, Co-stim = co-stimulation molecules (mainly CD28, ICOS, 41 BB, OX40), MHC Class 1 = major histocompatibility complex class I, TAA = tumor associated antigens.
