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. 2021 Jan 13;13(2):273. doi: 10.3390/cancers13020273

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunostaining of dyskerin in endometrial cancer subtypes (n = 109). (A) Representative microphotographs of dyskerin in human ECs. (1–3) grade 1–3 endometrioid carcinoma, (4) serous subtype, (5) Carcinosarcoma and (6) clear cell carcinoma. Positive staining appears brown. Magnification 400×. Scale bar 50 μm. (B) Dyskerin immunoscores in healthy PM (n = 30) and various EC subtypes including endometrioid (E) (n = 65), Serous (S) (n = 12), carcinosarcoma (CS) (n = 19), clear cell carcinoma (C) (n = 10), mixed cell adenocarcinoma (M) (n = 2) and dedifferentiated EC (DD) (n = 1). ** p < 0.01, **** p < 0.0001. Kruskal-Wallis test. (C) Dyskerin immunoscores in human endometrial epithelium of healthy PM (n = 30), LGEC (n = 53) and HGEC (n = 56). *** p < 0.001. Kruskal-Wallis test.