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Amyloid precursor protein (APP) processing by β- and γ-secretases. The single-pass membrane protein APP is proteolyzed just outside the transmembrane domain (TMD) by β-secretase. The remaining membrane-bound C-terminal fragment (APP CTF-β) is then cleaved within the TMD to produce the amyloid β-peptide (Aβ) and the APP intracellular domain (AICD).
