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Presenilin and other components of the γ-secretase complex. Presenilin is a 9-TMD protein that contains two TMD aspartates (D) essential to catalysis. Assembly of presenilin with the three other components—nicastrin, Aph-1, and Pen-2—triggers autoproteolysis of presenilin into an N-terminal fragment (NTF) and C-terminal fragment (CTF) to form the active γ-secretase complex.
