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Notch receptor processing and signaling. Interaction with a cognate ligand on a neighboring cell triggers Notch ectodomain shedding by the metalloprotease ADAM-10 and then cleavage of the Notch extracellular truncation (NEXT) fragment with its single TMD by γ-secretase. Release of the Notch intracellular domain (NICD) leads to translocation to the nucleus, activation of transcriptor factors, and gene expression that controls cell differentiation.
