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Representative helical peptide inhibitors (HPIs) and affinity labeling reagents for γ-secretase. Each depicted HPI is a d-peptide. Helix-inducing aminoisobutyric acid (Aib) residues are highlighted in red. Photoreactive 4-benzoyl-d-phenylalanine residues are blue, and linker-biotin moieties are in green.
