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Mitophagy induction shows different effects at early and late stages. Boosting mitophagy may be beneficial in the short term as mitochondriogenesis and the endolysosomal system work properly. However, this strategy may be detrimental in the long term due to progressive defects in both mitochondriogenesis and the endolysosomal system, resulting in the accumulation of nonfunctional vacuolated organelles.
