Table 1:

List of mechanisms associated with clinical triazole resistance in isolates of A. fumigatus.

Gene Name	Systematic Name Description	Alteration	Reference
cyp51A	Afu4g06890 14-alpha sterol demethylase	TR34/L98H	Mellado, E., et al., 2007 Snelders, E., et al., 2008 Gsaller, F., et al., 2016
cyp51A	Afu4g06890 14-alpha sterol demethylase	TR46/Y121F/T289A	Chowdhary, A., et al., 2014 Snelders, E., et al., 2015
cyp51A	Afu4g06890 14-alpha sterol demethylase	G54	Diaz-Guerra, T.M., et al., 2003
cyp51A	Afu4g06890 14-alpha sterol demethylase	G138	Manavathu, E.K., et al., 2000 Xiao, L., et al., 2004
cyp51A	Afu4g06890 14-alpha sterol demethylase	M220	Mellado, E., et al., 2004 Howard, S.J., et al., 2013
cyp51A	Afu4g06890 14-alpha sterol demethylase	G448S	Krishnan Natesan, S., et al., 2012 Bellete, B., et al., 2010
hapE	Afu2g14720 Sequence-specific CCAAT DNA binding transcription factor	P88L	Camps, S.M., et al., 2012
hmg1	Afu2g03700 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase	S269F	Hagiwara, D., et al., 2018
hmg1	Afu2g03700 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase	F262 deletion	Rybak, J.M., et al., 2019
hmg1	Afu2g03700 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase	S305P	Rybak, J.M., et al., 2019
hmg1	Afu2g03700 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase	I412S	Rybak, J.M., et al., 2019
cdr1B/ abcC	Afu1g14330 Putative ABC transporter	Overexpression	Fraczek, M.G., et al., 2013 Hagiwara, D., et al., 2016
atrF	Afu6g04360 Putative ABC transporter	Overexpression	Slaven, J.W., et al., 2002
mdr1	Afu5g06070 ABC multidrug transporter	Overexpression	Fraczek, M.G., et al., 2013 Nascimento, A.M., et al., 2003 Rajendran, R., et al., 2011
mdr2	Afu4g10000 ABC multidrug transporter	Overexpression	Fraczek, M.G., et al., 2013 Nascimento, A.M., et al., 2003 Rajendran, R., et al., 2011
Mdr3	Afu3g03500 Putative multidrug resistance protein	Overexpression	Nascimento, A.M., et al., 2003
Mdr4	Afu1g12690 ABC multidrug transporter	Overexpression	Nascimento, A.M., et al., 2003