Scheme 2.
Reagents and conditions: (a) NaBH4, EtOH, 0 °C to r.t., 55% (5a) and 19% (5b). (b) DIBAL-H, DCM, 0 °C to r.t., 55% (from 5a), 67% (from 5b), and 32% (from 4a). (c) Trifluoroacetic acid (TFA), MeOH, r.t., 85% (6a), 83% (6b), and 81% (6c).
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