Table 2.

Common irAEs.

irAE	Onset	Grade	Manifestation	Treatment
Dermatitis	Early (weeks)	1–2	Pruritis, maculopapular rash predominantly on trunk and extremities with facial sparing	Topical steroids or oral antihistamines, systemic steroids for Grade 3–4
Enterocolitis	Intermediate (weeks to months)	1–2, can be more severe	Diarrhoea, nausea, vomiting, abdominal pain, rectal bleeding	Antidiarrheal agents; Grade 3–4 is an emergency requiring supportive cares and systemic steroids
Thyroid dysfunction (hypo or hyperthyroidism)	Intermediate (weeks to months)	1–2	Signs/symptoms of hypo or hyperthyroidism	Hypothyroidism—thyroxine Hyperthyroidism—anti-thyroid drugs, radioactive iodine
Hepatitis	Intermediate (weeks to months)	1–2	Acute transaminitis	Systemic steroids in more severe cases