Skip to main content
. 2021 Jan 13;13(2):279. doi: 10.3390/cancers13020279

Figure 2.

Figure 2

Signal transduction via the signaling lymphocytic activation molecule family receptor (SLAMF) 2–SLAMF4 interaction. (A) On T cells, SLAMF2 promotes T cell receptor (TCR) signaling and T cell activation by binding to SLAMF4 on antigen-presenting cells (APCs) and activating the tyrosine kinase Lck in T cell membrane lipid rafts. (B) The SLAMF2–SLAMF4 interaction facilitates natural killer (NK) or T cell activation in the presence of sufficient levels of the adaptor protein SAP but induces an inhibitory signal in the absence of SAP.