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. 2021 Jan 13;13(2):279. doi: 10.3390/cancers13020279

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Signaling lymphocytic activation molecule family receptor (SLAMF) 3 signal transduction is mediated via self-ligation and cell–cell interactions. (A) SLAMF3 recruits SAP at two immunoreceptor tyrosine-based switch motif (ITSM) domains, and the SLAM–SAP–Fyn signaling pathway promotes T cell activation. (B) On multiple myeloma (MM) cells, SLAMF3 activates the ERK signal transduction pathway. This function is mediated via self-ligand interactions between MM cells and SHP2 and GRB2 formation, which accelerates cell proliferation and antiapoptotic signaling to increase the malignant potential of MM.