Skip to main content
. 2021 Jan 13;10(2):273. doi: 10.3390/jcm10020273

Table 1.

Favipiravir (FPV) dosing regimens used in various viral infections in humans presented in the best documented clinical trials.

Type of Viral Diseases FPV Dosage References
Treatment of uncomplicated influenza
Studies before drug registration
Low-dose regimen:
Day 1: 2000 mg (1000 mg twice a day)
Day 2–5: 800 mg (400 mg twice a day)
High-dose regimen:
Day 1: 2400 mg (1200 mg twice a day)
Day 2–5: 1600 mg (800 mg twice a day)
[20]
Day 1: 3600 mg (1800 mg twice a day)
Day 2–5: 1600 mg (800 mg twice a day)
[21]
Day 1: 3600 mg (1800 mg twice a day)
Day 2–5: 1600 mg (800 mg twice a day)
[22]
The approved FPV dose for influenza in Japan Day 1: 3200 mg (1600 mg twice a day)
Day 2–5: 1200 mg (600 mg twice a day)
[19]
Treatment of severe influenza patients (combination therapy FPV and oseltamivir) Day 1: 3200 mg (1600 mg twice a day)
Day 2–5: 1200 mg (600 mg twice a day)
[23]
Treatment of Ebola virus disease (EVD) Adults:
Day 1: 6000 mg ((first dose: 2400 mg; second dose (8 h after the first dose): 2400 mg; third dose (8 h after the second dose) 1200 mg.
Day 2–10: 2400 mg (1200 mg twice a day)
Children:
The dose was adapted according to body weight
[24]
Day 1: 1600 mg (800 mg twice a day)
Subsequent days, ranging from 3 to 11 days: 1200 mg (600 mg twice a day) until discharge, transfer, or death
[25]
Treatment of COVID-19 patients Day 1: 3200 mg (1600 mg twice a day)
Day 2–10: 1200 mg (600 mg twice a day)
[26]
Day 1: 3200 mg (1600 mg twice a day)
Day 2–14: 1200 mg (600 mg twice a day) plus interferon (IFN)-α by aerosol inhalation twice daily
[27]
Day 1: 3600 mg (1800 mg twice a day)
Day 2–14: 1600 mg (800 mg twice a day) plus standard supportive care
[28]
Day 1: 3600 mg (1800 mg twice a day)
Day 2 for a total of up to 19 doses over 10 days; 1600 mg (800 mg twice a day)
[29]
The first dose was 1600 mg or 2200 mg orally, followed by 600 mg each time, three times a day, and the duration of administration was not more than 14 days. [30]
Day 1: 3200 mg (1600 mg twice a day)
Day 2–14: 1200 mg (600 mg twice a day) or
Day 1: 3600 mg (1800 mg twice a day)
Day 2–14: 1600 mg (800 mg twice a day)
[31]