Table 1.
Type of Viral Diseases | FPV Dosage | References |
---|---|---|
Treatment of uncomplicated influenza Studies before drug registration |
Low-dose regimen: Day 1: 2000 mg (1000 mg twice a day) Day 2–5: 800 mg (400 mg twice a day) High-dose regimen: Day 1: 2400 mg (1200 mg twice a day) Day 2–5: 1600 mg (800 mg twice a day) |
[20] |
Day 1: 3600 mg (1800 mg twice a day) Day 2–5: 1600 mg (800 mg twice a day) |
[21] | |
Day 1: 3600 mg (1800 mg twice a day) Day 2–5: 1600 mg (800 mg twice a day) |
[22] | |
The approved FPV dose for influenza in Japan | Day 1: 3200 mg (1600 mg twice a day) Day 2–5: 1200 mg (600 mg twice a day) |
[19] |
Treatment of severe influenza patients (combination therapy FPV and oseltamivir) | Day 1: 3200 mg (1600 mg twice a day) Day 2–5: 1200 mg (600 mg twice a day) |
[23] |
Treatment of Ebola virus disease (EVD) | Adults: Day 1: 6000 mg ((first dose: 2400 mg; second dose (8 h after the first dose): 2400 mg; third dose (8 h after the second dose) 1200 mg. Day 2–10: 2400 mg (1200 mg twice a day) Children: The dose was adapted according to body weight |
[24] |
Day 1: 1600 mg (800 mg twice a day) Subsequent days, ranging from 3 to 11 days: 1200 mg (600 mg twice a day) until discharge, transfer, or death |
[25] | |
Treatment of COVID-19 patients | Day 1: 3200 mg (1600 mg twice a day) Day 2–10: 1200 mg (600 mg twice a day) |
[26] |
Day 1: 3200 mg (1600 mg twice a day) Day 2–14: 1200 mg (600 mg twice a day) plus interferon (IFN)-α by aerosol inhalation twice daily |
[27] | |
Day 1: 3600 mg (1800 mg twice a day) Day 2–14: 1600 mg (800 mg twice a day) plus standard supportive care |
[28] | |
Day 1: 3600 mg (1800 mg twice a day) Day 2 for a total of up to 19 doses over 10 days; 1600 mg (800 mg twice a day) |
[29] | |
The first dose was 1600 mg or 2200 mg orally, followed by 600 mg each time, three times a day, and the duration of administration was not more than 14 days. | [30] | |
Day 1: 3200 mg (1600 mg twice a day) Day 2–14: 1200 mg (600 mg twice a day) or Day 1: 3600 mg (1800 mg twice a day) Day 2–14: 1600 mg (800 mg twice a day) |
[31] |