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Empirical rules for predicting the oral availability and toxicity properties of the studied ligands.
| Properties | Oral Availability | Toxicity | |
|---|---|---|---|
| Lipinski Rules | Veber Rules | Pfizer 3/75 Rules | |
| MW | ≤500 | - | - |
| cLogP | ≤5 | - | ≤3 |
| HBA | ≤10 | - | - |
| HBD | ≤5 | - | - |
| TPSA | - | ≤140 | ≤75 |
| RB | - | ≤10 | - |
MW: Molecular weight; LogP: Octanol/water partition coefficient; HBA: Hydrogen bond acceptor; HBD: Hydrogen bond donor; TPSA: Topological polar surface area; RB: Rotatable bond count.
