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Experimental protocol for this study: (A) chemical structure of SAK3; (B) Experimental schedule for the present study. From day 14, 8-month-old ddY sham and OBX mice were subjected to a behavioral task 30 min after vehicle, SAK3 (0.5 mg/kg, p.o.) or Donepezil (1.0 mg/kg, p.o.) administration. After finishing the behavioral task, mice were sacrificed and their brains were removed for use in various experiments.
