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. 2021 Jan 13;9(1):74. doi: 10.3390/biomedicines9010074

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The whole body FLECT (Fluorescence Emission Computed Tomography)/CT (Computed Tomography) images of PFT-Hcy-HSA-Cy7-pTFT (A,B) and alb-TFT-AuNP (C,D) distribution at different time points in mice with severe combined immunodeficiency (SCID) with the brain tumor caused by the intracranial injection of a human glioblastoma cell line U87. Images were taken under the same conditions at 1 h (A,C) and 72 h (B,D) postinjection. Albumin conjugate PFT-Hcy-HSA-Cy7-pTFT accumulates in the malignant tissue (dotted line) of mouse brain 72 h after their intravenous injection (B). alb-TFT-AuNP conjugate predominantly localizes in liver (C,D). For a better visual display of the fluorescent label distribution in animals (A,B) and (C,D), different boundary conditions of the signal intensity scale were chosen.