Fig. 2.

Increased fractional use of the most frequently used TIS and decreased fractional use of each other TIS when translational amount rises. (A) Spearman’s correlation between the translational amount of a gene and the fractional uses of ranked TISs of the gene in human HEK293 cells. Each dot represents a gene. (B) Spearman’s correlation between the median translational amount of a supergene and the fractional uses of its ranked TISs in HEK293. Each dot represents a supergene. (C) Spearman’s correlation between the median expression level of a supergene and the fractional uses of its ranked TISs in each human and mouse sample examined. Sample IDs listed in the X-axis of (C) refer to those in supplementary table S1, Supplementary Material online. P < 0.05 in all cases.