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. 2020 Mar 7;37(7):2015–2028. doi: 10.1093/molbev/msaa063

Fig. 5.

Fig. 5.

Non-AUG initiation is generally nonadaptive. (A) Simpson or Shannon index of TIS codon diversity of a supergene in human HEK293 cells declines with the median translational amount of genes belonging to the supergene. Each circle or triangle represents a supergene. (B) Spearman’s correlation between translational amount and Simpson/Shannon index of TIS codon diversity among supergenes in each sample examined. P < 0.01 for all correlations. (C) Spearman’s correlation between the fractional use of each of the ten possible start codons in a supergene and the median translational amount of genes belonging to the supergene, shown by different colors. * indicates a statistically significant correlation (P < 0.05). (D) Fraction of genes in each sample for which the most frequently used translation start codon is AUG (blue), is not AUG but the AUG usage is not significantly lower than that of the most commonly used start codon (Q ≥ 0.05; purple), and is not AUG and the AUG usage is significantly lower than that of the most frequently used start codon (Q < 0.05; red), respectively. In (B) and (C), sample IDs listed in the X-axis refer to those in supplementary table S1, Supplementary Material online.