Figure 1.

The pathways of core metabolism in Vickermania ingenoplastis as compared to that of Leishmania major. Boxed metabolites are nutrients (in gray) or end-products (in black). PPP, pentose-phosphate pathway. Enzymes: 1, hexokinase; 2, phosphoglucose isomerase; 3, phosphofructokinase; 4, fructosebisphosphate aldolase; 5, triosephosphate isomerase; 6, glyceraldehyde-3-phosphate dehydrogenase; 7, glycosomal phosphoglycerate kinase; 8, glycerol-3-phosphate dehydrogenase; 9 glycerol kinase; 10, glycosomal adenylate kinase; 11, glucosamine-6-phosphate deaminase; 12, mannose-6-phosphate isomerase; 13, phosphomannomutase; 14, GDP-mannose pyrophosphorylase; 15, phosphoglycerate mutase; 16, enolase; 17, pyruvate kinase; 18, phosphoenolpyruvate carboxykinase; 19, malate dehydrogenase; 20, fumarate hydratase; 21, NADH-dependent fumarate reductase; 22, malic enzyme; 23, alanine aminotransferase; 24, aspartate aminotransferase; 25, pyruvate phosphate di-kinase; 26, citrate synthase; 27, 2-ketoglutarate dehydrogenase; 28, succinyl-CoA ligase; 29, succinate dehydrogenase; 30, acetate:succinate CoA transferase; 31, pyruvate dehydrogenase; 32, citrate lyase; 33, acetyl-CoA synthetase; 36, ribulokinase; 37, ribokinase, 38, xylulokinase; 39, glucoamylase; 40, invertase; 41, glyoxalase I; 42, glyoxalase II; 43, D-lactate dehydrogenase; 44, GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase; 45, phosphoacetylglucosamine mutase and glucosamine-1-phosphate acetyl transferase/UDP-N-acetylglucosamine transferase; 46, alcohol dehydrogenase GroES-like domain/zinc-binding dehydrogenase; 47, pyruvate decarboxylase; 48, methylmalonyl-CoA epimarase; 49, methylmalonyl-CoA mutase; 50, propionyl-CoA carboxylase. Modified from [25].