Table 1.

Prospects of COVID-19 therapies based on extracellular neutrophil traps (NETs) blocking and anti-inflammatory action.

	Treatment	Target	Action
Inhibition of NETs formation	NE inhibitors: - Sivelestat - Lonodelestat - Alvelestat - Alafina - CHF6333	NE	Antiprotease
	PAD4 inhibitor: - Cl-amidine	PAD4	Inhibition of histone citrullination
	Gasdermin D inhibitor: - Disulfiram	Gasdermin D	Inhibition of pore generation in the cell membrane
	Dipyridamole	A2A adenosine receptors	Adenosine uptake inhibitor
	Aspirin	NF-κB p65 signaling pathway	Decrease in NETs formation
NETs dissolution induction	Dornase alfa	DNA	DNA degradation
Blocking IL-1β activity	IL-1β inhibitors: - Anakinra - Canakinumab - Rilonacept	IL-1β	Disrupting the feedback loop IL-1β/NETs
	Colchicine	- Neutrophils - IL-1β	- Inhibition of neutrophil recruitment - Blocking the secretion of IL-1β
Anti-inflammatory effect	Glyburide	ATP-sensitive K+ channels	Blocking the activation of the NLRP3 inflammasome
	Metformin	Alarmin HMGB1	Suppressing proinflammatory properties