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. 2021 Jan 14;10(1):153. doi: 10.3390/cells10010153

Figure 4.

Figure 4

Recruitment of basket nucleoporin NUP153 and scaffold nucleoporin NUP107 was not affected in HGPS. Immunocytochemistry of (a) control (GMO1651c) and (b) HGPS (HGADFN127) fibroblasts using α-NUP107 and α-NUP153 antibodies, counterstained with DAPI. NPCs cluster in interphase HGPS cells (b), unlike the evenly distributed punctate pattern in control interphase (a). Recruitment of NUP153 to anaphase chromosomes is not affected in HGPS cells when compared to control. No defect in NUP153 or NUP107 localization can be observed in HGPS from prophase to cytokinesis. n ≥ 3.