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. 2021 Jan 14;10(1):153. doi: 10.3390/cells10010153

Figure 5.

Figure 5

SUN1 aggregates did not colocalize with mAb414. Immunocytochemistry of (a) control (GMO1651c) and (b) HGPS (HGADFN127) fibroblasts using mAb414 and α-SUN1 antibodies, counterstained with DAPI. NPCs cluster in interphase HGPS cells (b) and the aggregates colocalize with SUN1 aggregates. In metaphase to cytokinesis, SUN1 forms aggregates in the ER of mitotic HGPS cells, which are absent in control cells. Recruitment of mAb414 to late anaphase/telophase chromosomes is not affected in HGPS cells. n ≥ 3.