Table 2.

Genomic alterations in hyperprogressors vs. in non hyperprogressors.

Gene	HPD Mutated	Non-HPD Mutated	p-Value
TP53	4 (50%)	7 (63.6%)	0.658
PI3K/PTEN/FAT1	2 (25%)	3 (27.3%)	1.000
RAS/EGFR	1 (12.5%)	2 (18.5%)	1.000
No mutation	1 (12.5%)	3 (27.3%)	0.603
Gene amplification	4 (50%)	2 (18.3%)	0.319
EGFR amplification	2 (25%)	0 (0%)	0.164
Categories	HPD Mutated	Non-HPD Mutated	p-Value
Growth factors	4 (50%)	6 (54.5%)	1.000
DNA damage errors	5 (62.5%)	5 (62.5%)	0.650
Transcription factors Epigenetic	2 (25%)	3 (27.3%)	1.000
Ubiquitin Proteasome	0 (0%)	1 (9.1%)	1.000