Table 2.
In vivo studies of BBs on brain health protection.
| Consumption Type/Animal Models | Key Results | References |
|---|---|---|
| BB supplementation/Fischer 344 rats | A decrease in the activation of microglia | [42] |
| Dried aqueous extract/Fischer 344 rats | Reversing age-related deficits in several neuronal signaling pathways and behaviors | [43] |
| BB extract/Fischer 344 rats | Increasing hippocampal plasticity parameters, IGF-1 and IGF-1R levels | [44] |
| BB diet/Sprague-Dawley rats | Anti-inflammatory activity in post-traumatic stress disorder | [45] |
| Freeze-dried BBs/C57Bl/6 mice | Fewer microglia and increased neuroplasticity in the brains of high-fat diet mice than in those of high-fat diet mice who did not consume BBs and of low-fat diet mice | [46] |
| Dietary supplementation with BBs and fat diets/C57BL6/J mice | Greatest benefits for age-related neurodegenerative disorders when consumed with a low-fat diet | [47] |
| BB extract/a mixture of C57BL/6, DBA, SJL and Swiss Webster mice |
Enhancing the memory-associated neuronal signaling pathway and modifying neutral sphingomyelin-specific phospholipase C activity | [48] |
| BB extract/APP/PS1 transgenic mice | A connection between the expression of proteins involved in cognitive dysfunction and the improvement of this impairment | [49] |