Table 1.

Multivariable Analysis of Risk Factors for Grade 3 or Higher Transaminase Elevation

Variable	HR (95% CI)	p-Value
Prior therapy
Yes	0.47 (0.35, 0.63)	<0.001
Age, y+
<55	2.64 (1.50, 4.63)	0.003
≥55 to <65	1.77 (1.07, 2.91)
≥65 to <75	1.36 (0.84, 2.21)

^*Factors considered: IGHV mutation, del(17p), age, combination with BR, prior therapy, and their interactions

⁺Compared with ≥75 y.

CI, confidence interval; HR, hazard ratio