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. 2021 Jan 20;14:265–277. doi: 10.2147/DMSO.S280765

Figure 1.

Figure 1

Expression of EPB41L4A-AS1 and inflammatory factors in PBMC of T2DM patients, and experimental induction of PBMC and THP-1 cells by HG and high-fat conditions. (A) EPB41L4A-AS1 expression was decreased in the PBMC of T2MD patients compared with those of healthy individuals (GEO dataset GDS3875). (B–C) Expression of inflammatory factors IL-1β and IL-8 in PBMC of T2DM patients (GEO dataset GDS3874). (D) EPB41L4A-AS1 expression in PBMC after 55 mM HG + 250 μmol/L PA treatment for 12 h (n=3). (E) EPB41L4A-AS1 expression in THP-1 cells after 55 mM HG + 250 μmol/L PA treatment for 2–12 h (n=3). (F) IL-1β and IL-8 mRNA expression in PBMC after 55 mM HG + 250 μmol/L PA treatment for 12 h (n=3). (G) IL-1β and IL-8 mRNA expression in THP-1 cells after 55 mM HG + 250 μmol/L PA treatment for 6 h (n=3). (H) IL-1β and IL-8 protein expression in cell lysate of THP-1 cells after 55 mM HG + 250 μmol/L PA treatment for 6 h (n=3). (I) IL-8 protein expression in medium of THP-1 cells after 55 mM HG + 250 μmol/L PA treatment for 6 h (n=3). Data are shown as mean ± SD. *P<0.05, **P<0.01, ***P<0.001; Student’s t-test. HG, high glucose; NC, untreated; PA, palmitic acid.