BVT and BVC changes between control and SCR patients. (A1-A4) a-BVT, v-BVT, m-BVT and AVR-BVT differences between control and SCR stages. (B1-B4) a-BVC, v-BVC, m-BVC and AVR-BVC differences between control and SCR stages. *, moderately significant change compared to control (P<0.05); **, highly significant change compared to control (P<0.001); †, moderately significant change between two SCR stages. Reprinted from Ref. (24).