Table 2.
Population stratified in two groups according to the therapy: BAT or BAT plus oral bacteriotherapy.
| Parameters | BAT (n = 112) | BAT + oral bacteriotherapy (n = 88) | p-value | ||||
|---|---|---|---|---|---|---|---|
| Mean (±SD) | Median (IQR 25–75%) | Number (%) | Mean (±SD) | Median (IQR 25–75%) | Number (%) | ||
| Gender, Male/Female | – | – | 64 (57)/48 (43) | – | – | 49 (56)/39 (44) | 0.978 |
| Age | 64 (±16) | 63 (55–75) | – | 62 (±15) | 63 (52–72) | – | 0.289 |
| Age > 65 years | – | – | 53 (47) | – | – | 38 (43) | 0.448 |
| Lymphocytes <1,000 (mmc) | – | – | 60 (54) | – | – | 49 (56) | 0.898 |
| PLT <150,000 (mmc) | – | – | 16 (14) | – | – | 22 (25) | 0.718 |
| Albumin <32 (mg/dl) | – | – | 20 (18) | – | – | 7 (8) | 0.024 |
| CRP >41.8 (mg/L) | – | – | 64 (57) | – | – | 40 (45) | 0.055 |
| White blood cells (mmc) | 6,306 (±2,624) | 5,740 (4,570–7,450) | – | 6,206 (±2,944) | 5,590 (4,327–7,155) | – | 0.803 |
| Neutrophils (mmc) | 4,716 (±2,525) | 4,100 (2,990–5,689) | – | 4,473 (±2,785) | 3,785 (2,692–5,592) | – | 0.528 |
| Neutrophils (%) | 72 (±12.7) | 73 (65–80) | – | 69 (±13.5) | 68 (61–79) | – | 0.076 |
| Lymphocytes (mmc) | 1,013 (±517) | 920 (640–1,300) | – | 1,168 (±775) | 925 (687–1,350) | – | 0.111 |
| Lymphocytes (%) | 18 (±9.9) | 16 (12–24) | — | 20 (±11.4) | 18 (11–28) | – | 0.162 |
| Monocytes (mmc) | 368 (±168) | 320 (250–450) | 354 (±151) | 325 (240–470) | – | 0.562 | |
| C-reactive protein (mg/L) | 11,645 (±133,032) | 63,540 (22,375–160,770) | – | 77,257 (±101,404) | 34,900 (12,375–113,970) | – | 0.020 |
| D-dimer (mg/dl) | 1,444 (±1,199) | 1,268 (627–3,147) | – | 1,193 (±1,212) | 788 (484–1,770) | – | 0.188 |
| Albumin (mg/dl) | 35.9 (±5.8) | 37 (32.0–40) | – | 38.1 (±5.4) | 39.0 (34–42) | – | 0.008 |
| LDH (U/L) | 358.9 (±1,923) | 310 (242.3–419.3) | – | 300.8 (±126) | 272.0 (211–379) | – | 0.012 |
| CHARLSON index | 2.7 (±2.3) | 2 (1–4) | – | 2.3 (±2.0) | 2 (1–4) | – | 0.313 |
| Body Mass Index (BMI) | 23 (±3) | – | – | 24 (±2) | – | – | 0.13 |
| CURB-65 | 1 (±1) | 1 (0–2) | – | 1 (±1) | 1 (0–2) | – | 0.395 |
| EXP CURB 65 | 2 (±1) | 2 (1–3) | – | 2 (±1) | 2 (1–3) | – | 0.108 |
| PSI | 76 (±31) | 73 (54–91) | – | 71 (±28) | 69 (49–86) | – | 0.211 |
| CALL | 9 (±3) | 9 (7–11) | – | 9 (±3) | 9 (7–11) | – | 0.869 |
| Lenght of hospitalization (days) | 18 (±13) | 14 (8–23) | – | 23 (±14) | 20 (11–31) | – | 0.012 |
| Intensive care unit (ICU) hospitalization | – | – | 24 (19) | – | – | 16 (18) | 0.847 |
| History of CV disease | – | – | 0 (0) | – | – | 0 (0) | 1.000 |
| Death | – | – | 34 (30) | – | – | 10 (11) | < 0.001 |
| Bloodstream infection (BSI) | – | – | 14 (13) | – | – | 7 (8) | 0.211 |
| Lung superinfections | – | – | 9 (8) | – | – | 8 (9) | 0.904 |
| Fungal infections | – | – | 2 (2) | – | – | 0 (0) | 0.158 |