Table 2.
Results from included articles on NSAIDs and Tc during exercise.
| Bruning et al.18 | de Meersman40 | Hostler et al.37 | Lambert et al.41 | McEntire et al.40 | |
|---|---|---|---|---|---|
| Participants | N = 14 Males and females Age = 55 ± 1 years V̇O2peak = 29.5 ± 1.7 mL/kg/min | N = 8 Males Age 21–34 years Baseline V̇O2max not reported | N = 102 Male and female firefighters Age = 31.9 ± 9.1 years V̇O2max = 44.6 ± 7.2 mL/kg/min | N = 17 Males and females Age = 27 ± 1 years V̇O2max = 62.2 ± 2.1 mL/kg/min | N = 15 Male firefighters Age = 30.5 ± 9.3 years V̇O2max = 46.6 ± 7.0 mL/kg/min |
| NSAID | Aspirin | Aspirin | Aspirin | Aspirin | Aspirin |
| Dose | 81 mg 1 x day for 7–10 days | 500 mg 6 x day for 1 day | 81 mg/day for 14 days | 325 mg 4 x day for 1 day | 81 mg/day for 14 days |
| Timinga | Morning of trial | Last dose not reported; mean drug concentration = 17 ± 8 mg/100 mL | Morning of trial | Morning of trial | Last dose not reported |
| Exercise | 120 min recumbent cycle at 60% V̇O2peak | 60 min run at 50% V̇O2max | 50 min intermittent walking at 4.5 km/h with 2.5% incline and 2.5 km/h with 0% incline | 60 min run at 70% V̇O2max | 45 min walk at 6.4 km/h |
| Environment | 30 °C dry/22 °C wet bulb, 40% RH | 18 ± 0.5 °C, 43 ± 2% RH | 38.9 ± 1.1 °C, 19.8 ± 3.8% RH | 22.4 °C, 48% RH | 38.8 ± 2.1 °C, 24.9 ± 9.1% RH |
| Tc Measure | Esophageal | Rectal | Ingestible thermistor | Rectal | Ingestible thermistor |
| Tc Results | NSAID range ≈37.1–38.2 °C, significantly higher than control range ≈36.6–37.9 °C, p < .001 | At 60 min NSAID = 38.2 ± 0.52 °C and control = 37.9 ± 0.56 °C No significant difference, p > .05 |
Range ≈36.7–39.4 °C No significant difference, p > .05 |
Mean = 38.4 ± 0.1 °C No significant difference, p > .05 |
At 45 min NSAID = 39.0 ± 0.7 °C and control = 39.1 ± 0.6 °C No significant difference, p = .69 |
| Emerson et al.42 | Farquhar & Kenney38 | Farquhar et al.39 | Bradford et al.43 | |
|---|---|---|---|---|
| Participants | N = 11 Males and females Age = 27.8 ± 6.5 years V̇O2max = 41.4 ± 5.7 mL/kg/min |
N = 16 Females Younger age = 24 ± 2 years Older age = 64 ± 2 years Younger V̇O2max = 41.2 ± 2.2 mL/kg/min Older V̇O2max = 29.1 ± 1.7 mL/kg/min |
N = 12 Males and females Age = 25 ± 1 years V̇O2max = 54 ± 1 mL/kg/min |
N = 10 Males Age = 23 ± 5 years V̇O2max = 53.1 ± 5.3 mL/kg/min |
| NSAID | Naproxen | Ibuprofen | Ibuprofen | Rofecoxib |
| Dose | 220 mg 3 x day for 1 day | 400 mg 3 x day for 3 days | 400 mg 3 x day for 4 days | 25 mg 2 x day for 6 days |
| Timinga | ∼1 h before | ∼30 min before | Morning of trial | ∼1½ hours before |
| Exercise | 80 min cycling at 70% V̇O2max then 10 min at max effort | 60 min walk at 60% V̇O2max | 45 min run at 65% V̇O2max | 45 min run at ∼75% V̇O2max then 45 min cycle at matched perceived intensity |
| Environment | 35.7 ± 1.3 °C, 53.2 ± 3.2% RH 22.7 ± 1.8 °C, 52.4 ± 5.5% RH |
36 °C dry/24 °C wet bulb | 36 °C dry/24 °C wet bulb | 28 °C, 50% RH |
| Tc Measure | Rectal | Rectal | Rectal | Rectal |
| Tc Results | At 90 min mean = 38.2 ± 0.3 °C No significant difference, p > .05 |
At 60 min, younger NSAID = 38.74 ± 0.08 °C and control = 38.81 ± 0.10 °C; older NSAID = 38.50 ± 0.16 °C and control = 38.45 ± 0.13 °C No significant difference, p > .05 |
At 45 min NSAID = 39.2 ± 0.1 °C and control = 38.9 ± 0.1 °C No significant difference, p > .05 |
Run range ≈37.2–38.0 °C No significant difference, p > .05 Cycling NSAID range ≈36.7–37.2 °C significantly lower than control range ≈37.3–37.8 °C, p < .05 |
Abbreviations: RH = relative humidity; Tc = core temperature; V̇O2max = maximal oxygen consumption; V̇O2peak = peak oxygen consumption.
a
Timing refers to when the last NSAID dose was taken prior to exercise.