Figure 2.

Clinical, histological and immunological features of pemphigus and pemphigoid. (A) Clinical presentation of pemphigus vulgaris with erosions at the upper palate. (B) Clinical presentation of bullous pemphigoid with blistering at erythematous or otherwise apparently healthy skin. (C) Lesional histopathology of a patient with pemphigus vulgaris showing suprabasal splitting with some acantholysis and the typical “row of tombstones” (arrows). (D) In a lesional biopsy of a patient with bullous pemphigoid, subepidermal splitting. In this case, interestingly, the dermal infiltrate is only marginally present. (E) Tissue-bound IgG in a perilesional skin biopsy of a pemphigus vulgaris patient, showing IgG deposits in a honeycomb-like pattern within the epidermis. (F) Tissue-bound IgG in a perilesional skin biopsy of a bullous pemphigoid patient, showing linear IgG deposits along the dermal-epidermal junction.