Table 2.
Kinetic values for C1q interaction components on mAb opsonized cells as extracted by global InteractionMap analysis for each condition.
| Strong interaction component | |||||
|---|---|---|---|---|---|
| ka1 (1/(M*s)) | kd1 (1/s) | KD1 (M) | half-life (min) | fraction binding sites | |
| RTX-Ramos | 5.2E+04 | 4.8E-05 | 9.3E-10 | 240 | 0.15 |
| RTX-Daudi | 3.4E+04 | 7.8E-05 | 2.3E-09 | 147 | 0.13 |
| RTX-P493.6 | 6.7E+04 | 5.6E-05 | 8.3E-10 | 208 | 0.20 |
| RTX-LCL1.11 | 3.4E+04 | 4.0E-05 | 1.2E-09 | 286 | 0.17 |
| OFA-Ramos | 2.3E+05 | 1.7E-05 | 7.1E-11 | 694 | 0.77 |
| OFA-Daudi | 1.1E+05 | 2.1E-05 | 1.9E-10 | 558 | 0.42 |
| OFA-P493.6 | 1.5E+05 | 1.7E-05 | 1.1E-10 | 700 | 0.43 |
| OFA-LCL1.11 | 7.6E+04 | 1.8E-05 | 2.4E-10 | 649 | 0.85 |
| Weak interaction component | |||||
| ka2 (1/(M*s)) | kd2 (1/s) | KD2 (M) | half-life (min) | fraction binding sites | |
| RTX-Ramos | 2.0E+05 | 1.4E-02 | 7.0E-08 | 1 | 0.85 |
| RTX-Daudi | 1.8E+05 | 9.1E-03 | 4.9E-08 | 1 | 0.87 |
| RTX-P493.6 | 2.1E+05 | 6.7E-03 | 3.2E-08 | 2 | 0.80 |
| RTX-LCL1.11 | 1.5E+05 | 9.8E-03 | 6.4E-08 | 1 | 0.83 |
| OFA-Ramos | 1.0E+06 | 5.3E-03 | 5.1E-09 | 2 | 0.23 |
| OFA-Daudi | 6.1E+05 | 8.8E-03 | 1.4E-08 | 1 | 0.58 |
| OFA-P493.6 | 4.5E+05 | 8.8E-03 | 2.0E-08 | 1 | 0.57 |
| OFA-LCL1.11 | 5.7E+05 | 4.3E-03 | 7.6E-09 | 3 | 0.15 |