Table 1.
Latency Type | Viral mRNAs | Viral noncoding RNAs | Immunogenicity* | |
---|---|---|---|---|
Latency I | Canonical BL | EBNA1 | BART miRNAs EBERs |
Limited antigen expression |
Wp Latency | Wp-restricted BL | EBNA1 EBNA3A, 3B, 3C EBNA-LP (truncated) BHRF1 |
BART miRNAs EBERs BHRF1 miRNAs |
Increased antigen expression |
Latency III | LCLs | EBNA1 EBNA2 EBNA3A, 3B, 3C EBNA-LP BHRF1 LMP1 LMP2A, 2B |
BART miRNAs EBERs BHRF1 miRNAs |
Highest antigen expression |
*Rowe et al., 1986; Rooney et al., 1986; Rowe et al., 1987.
Annotations in acronym or abbreviated form are: LCL, lymphoblastoid cell line.