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. 2021 Jan 11;14:618422. doi: 10.3389/fnins.2020.618422

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Copyright © 2021 Kovács, Brunner, D’Agostino and Ari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sex-dependent changes in blood glucose levels. Control glucose levels were different (lower) in male rats, compared with female rats only at the 16th and 17th months (A). KEMCT treatment-generated blood glucose levels were significantly lower in female than male rats at the 1st, 2nd, 4th, 7th, and 8th months, but it was higher at the 17th month (B). Differences between KEMCT-evoked glucose levels and control glucose levels did not show significant alterations between sexes (C). KEMCT, mix of ketone ester (KE) and medium-chain triglyceride (MCT) oil in a 1:1 ratio. *p < 0.05; **p < 0.01; ****p < 0.0001.