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. 2021 Jan 11;8:579236. doi: 10.3389/fcell.2020.579236

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Copyright © 2021 Han, Yang, Hao, Zhang, Zhang, Xin and Hao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In silico analyses of miR-410 in regulating the HDAC1/EGR2/Bcl2 axis. (A) The Venn diagram of downstream target genes of mouse miR-410 predicted by DIANA TOOL, miRDB, miRWalk, StarBase, TargetScan, and microRNA database. (B) The binding sites between miR-410 and HDAC1 in mice and human determined by StarBase. The above rectangle represents the binding site for mice (mmu), and the lower rectangle represents the binding site for humans (hsa). (C) Volcano plot of gene expression dataset GSE23160. Green dots indicate significantly downregulated genes and red dots indicate significantly upregulated genes. (D) The Venn diagram of intersection among co-expressed genes, the DEGs and human transcription factors from the database hTFtarget. (E) The targeting relationship between EGR2 and Bcl2 predicted by hTFtarget.