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. 2021 Jan 11;8:571948. doi: 10.3389/fcell.2020.571948

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Copyright © 2021 Delort, Cholet, Decombat, Vermerie, Dumontet, Castelli, Fenaille, Auxenfans, Rossary and Caldefie-Chezet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Percentage of myoepithelial cell (MEC) viability when co-cultured with adipose cells from women of different BMI (A) or with their adipose secretome (B). (A) MECs were co-cultured for 72 h with human adipose stem cells (hASCs) extracted from women of normal weight (hASC20) and obese women (hASC30) and differentiated into mature adipocytes (MA20 and MA30); (B) MECs were cultured for 72 h with conditioned media (CM) obtained from hASCs (CM[hASC20] and CM[hASC30]) or MAs (CM[MA20] and CM[MA30). Results are expressed as Percentage of MEC growth ± SEM (n = 8 for hASCs and MAs, n = 3 for CM; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001).