TABLE 2.

Characteristics of the different metabolites.

Metabolites	Retention time (min)	Mass-to-charge ratio	VIP value	Fold change	P-value
Between the AIS and HCs groups
Oleic acid	5.116	281.249	2.107	2.216	<0.00001
Linoleic acid	4.465	279.233	1.844	1.970	0.00001
Cer (d18:0/14:0)	8.993	512.503	1.735	0.212	<0.00001
Cer (d18:0/16:0)	9.546	540.534	1.732	0.213	<0.00001
Arachidonic acid	4.421	303.233	1.556	1.564	0.00030
Non-adecanoic acid	6.306	297.280	1.371	0.652	<0.00001
Docosahexaenoic acid	4.207	327.233	1.306	1.342	0.00964
4-Hydroxyproline	5.939	132.066	1.270	0.520	<0.00001
PE[18:2(9Z,12Z)/18:1(9Z)]	8.534	742.538	1.099	0.492	<0.00001
PE[18:2(9Z,12Z)/18:0]	8.989	744.553	1.099	0.514	<0.00001
L-Palmitoylcarnitine	1.433	400.342	1.098	1.338	<0.00001
Propionylcarnitine	2.604	218.139	1.097	0.716	<0.00001
Tetradecanoylcarnitine	1.473	372.311	1.095	1.382	0.00015
L-Glutamine	6.353	147.077	1.094	0.810	<0.00001
L-Arginine	7.316	175.119	1.093	0.742	<0.00001
Dodecanoylcarnitine	1.522	344.280	1.094	1.349	0.00695
L-Proline	5.346	116.071	1.092	0.758	<0.00001
Decanoylcarnitine	1.593	316.248	1.090	1.330	0.02110
Between the LAA and SAO group
L-Pipecolic acid	4.735	130.087	1.578	1.790	0.00065
1-Methylhistidine	7.267	170.093	1.317	1.625	0.04886
PE [22:6(4Z,7Z,10Z,13Z,16Z,19Z)/16:0]	8.209	764.521	1.270	0.780	0.02704
PE [P-18:0/18:2(9Z,12Z)]	9.314	728.557	1.192	1.276	0.01645
LysoPE [18:2(9Z,12Z)/0:0]	2.428	478.292	1.113	1.446	0.00011
LysoPC [18:3(9Z,12Z,15Z)]	1.991	518.323	1.045	1.387	0.00144
LysoPC (20:0)	5.009	552.402	1.033	1.254	0.00669
LysoPC [18:2(9Z,12Z)]	2.455	520.339	1.000	1.336	0.00013

LAA, large artery atherosclerosis; SAO, small artery occlusion; AIC, acute ischemic stroke; HC, healthy control; PE, phosphatidylethanolamine.