Figure 5.

Longitudinal analysis of insulin sensitivity before and after pregnancy. Fasting glucose, insulin, HOMA-IR and AUC of glucose and insulin during an ivGTT were compared for those animals that became pregnant at pre-pregnancy (∼6 months before mating), and then at 3–4 months and 16–17 months post-pregnancy termination (third trimester). Data are presented as means ± SEM (C n = 9, T n = 9, WSD n = 7 and T + WSD n = 3). Significant effects of WSD and/or T or interactions over time as determined by a mixed models ANOVA are presented as text within the graphs. C, Control; HOMA-IR, Homeostatic Model Assessment of Insulin Resistance; ivGTT, intravenous glucose tolerance test; T, testosterone; WSD, Western-style diet.