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. 2021 Jan 11;8:613892. doi: 10.3389/fcell.2020.613892

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Copyright © 2021 Chornyi, IJlst, van Roermund, Wanders and Waterham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Currently known ATP-dependent enzymatic reactions in the peroxisomes and transport of ATP, AMP and PP. Intraperoxisomal ATP is required for the ACSVL-mediated activation of fatty acids after their import by the ABCD proteins. Pristanic acid formed during alpha-oxidation is activated inside peroxisomes to the corresponding CoA ester in an ATP-dependent reaction. Finally, the peroxisomal protease LonP2 hydrolyzes ATP. It is unknown which transporter mediates the import of ATP into peroxisomes. The products of ATP hydrolysis – AMP and PP are exported from peroxisomes most probably by PMP34 and PXMP2, respectively.