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. 2021 Jan 16;22(2):862. doi: 10.3390/ijms22020862

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Confocal images of F-actin distribution pattern in MCF-10A (A,B) and MCF-7 (C–E) cultured in normal gravity (OG) and microgravity (RPM) conditions for 24 h. MCF-10A cells cultured in RPM conditions (B) show actin bundles orthogonal to the periphery of plasma membrane (arrows; scale bar 37.50 μm), while F-actin fibers appear well-organized in MCF-7 cultured in the on-ground condition (C, arrows, scale bar 20 μm). In RPM-AD cells, stress fibers are slightly reduced, while F-actin was mostly localized at the cell border (D). On the contrary, in RPM-CLUMPS cells the actin filaments are fragmented and significantly reduced (E), mostly positioned at the perinuclear level of floating cells €.