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. 2021 Jan 26;9(3):528–539. doi: 10.12998/wjcc.v9.i3.528

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Potential mechanisms of liver injury in patients with coronavirus disease 2019. 1: Severe acute respiratory syndrome coronavirus-2 may directly bind to angiotensin converting enzyme II positive cholangiocytes to dysregulate liver function; 2: Inflammatory cytokine storm leads to persistent activation of lymphocytes and macrophages that secrete huge amount of inflammatory cytokine, thus contributing to lung as well as liver damage; 3: Drugs including antipyretics, antiviral medications (lopinavir/ritonavir), antibiotics (macrolides, quinolones) and steroids may have potential hepatotoxicity and lead to abnormal liver function; 4: Hepatic ischemia and hypoxia-reperfusion dysfunction induced by complications such as respiratory failure may cause liver damage, especially in critically ill patients.