Table 1.
Baseline characteristics of the study population subdivided by gender identity.
| TW (n = 451) | TM (n = 422) | |||
|---|---|---|---|---|
| Age (years) | 27.0 [22.0–41.0] | 22.0 [20.0–28.0] | ||
| Baseline PA scores | 32.5 [27.0–37.0] | 33.0 [27.0–38.0] | ||
| Baseline NA scores | 14.0 [12.0–19.0] | 14.0 [12.0–19.0] | ||
| Gender-affirming hormonal therapy | Testosterone (60 missing) | AG 25 mg once daily | 18 (5.0%) | |
| AG 50 mg once daily | 106 (29.3%) | |||
| TU 1 g once every 12 weeks | 121 (33.4%) | |||
| TE once every 2 weeks | 112 (30.9%) | |||
| TE once every 3 weeks | 4 (1.1%) | |||
| Anti-androgens | CPA 50 | 451 (100%) | ||
| Estrogens (76 missing) | Gel | 4 (1.1%) | ||
| EV | 219 (58.4%) | |||
| Patch 100 mcg/72 h | 108 (39.2%) | |||
| Patch 50 mcg/72 h | 12 (4.4%) | |||
| Patch 75 mcg/72 h | 2 (0.7%) | |||
| Number of TM reporting menstruation (%) (184 missing) | 39 (16.4%) | |||
| Number of TM reporting spotting (%) (180 missing) | 31 (12.8%) | |||
| Number of TM using contraceptives (%) | 72 (15.9%) | |||
| Median Ferriman and Gallwey score | 1.0 [0.0–3.0] | |||
| Serum estradiol levels (pg/mL) | 25.3 [21.1–30.1] | 36.9 [22.5–76.8] | ||
| Serum testosterone levels (nmol/L) | 18.5 [14.0–23.3] | 1.2 [0.9–1.6] | ||
| Serum LH levels (U/L) | 3.9 [2.7–5.3] | 4.5 [2.4–7.7] | ||
| Serum FSH levels (U/L) | 3.5 [2.3–4.9] | 5.6 [3.3–7.2] | ||
| Serum SHBG levels (ng/dL) | 54.7 [35.0–81.0] | 36.8 [26.7–51.3] | ||
| Median Utrecht Gender Dysphoria (UGDS) scores | 22.0 [16.0–47.0] | 29.0 [28.0–32.0] | ||
| Median quality of life (QOL) scores | Total | 8.0 [7.0–9.0] | 8.0 [7.0–9.0] | |
| Social | 30.0 [26.0–33.0] | 30.0 [26.0–34.0] | ||
| Median total SCL-90-R, Symptom Checklist scores (SCL-90R) | 23.0 [8.0–47.3] | 23.0 [10.0–54.0] | ||
TW = transgender women, TM = transgender men, PA = PANAS positive affect scores, NA = PANAS negative affect scores, AG = androgen gel, TU = testosterone undecanoate, TE = testosterone esters, CPA = cyproterone acetate, EV = estradiol valerate, LH = luteinizing hormone, FSH = follicle stimulating hormone, SHBG = sex hormone binding globulin.