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. 2021 Jan 17;13(1):122. doi: 10.3390/v13010122

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Evaluation of the replication and pathogenesis of recombinant viruses icPDCoV, icPDCoV-S_HKU17 and icPDCoV-RBD_ISU in 4-day-old Gn piglets. OH-FD22 group was positive control. Each line represents the mean value of each group and the values of individual Gn piglets are also shown: (A) Fecal consistency scores (0, solid; 1, pasty; 2, semiliquid; and 3, liquid. score of ≥2 was considered diarrhea.), (B) Fecal PDCoV RNA shedding profile, (C) Nasal PDCoV RNA shedding profile, and (D) Infectious PDCoV shedding titers from fecal samples.