Table 1.
General litter information and clinical signs of piglets after inoculation.
| Inoculation Group | No. of Pigs | Inoculation Route (No. of Pigs) | Diarrhea Rate (%) b | Onset of Diarrhea (dpi) a,c | Mean Cumulative Fecal Consistency Score of Each Pig b,c,d | Duration of Diarrhea (Days) a | Peak Nasal RNA Shedding Titer (log10 Copies/mL) [dpi] a,e | Peak Fecal RNA Shedding Titer (log10 Copies/mL) [dpi] a,e |
|---|---|---|---|---|---|---|---|---|
| icPDCoV | 4 | Oral (4) | 100 A | 1.50 ± 0.58 | 2.78 ± 2.12 A | 10.5 ± 0.58 | 6.88 ± 0.70 [2.5] | 8.375 ± 0.81 [1.5] |
| OH-FD22 | 3 | Oral (3) | 100 A | 2.00 ± 0.00 | 1.88 ± 1.76 A | 10 ± 0.00 | 6.85 ± 1.46 [2] | 8.92 ± 0.25 [2] |
| icPDCoV-SHKU17 | 5 | Oral (3) Oronasal (2) |
0 B | ND | 0.22 ± 0.19 B | ND | 6.06 ± 1.42 [4] | ND |
| icPDCoV-RBDISU | 2 | Oral (2) | 0 B | ND | 0.5 ± 0.00 B | ND | 5.08 [2] f | ND |
| Mock | 2 | Oral (2) | 0 B | ND | 0.5 ± 0.50 B | ND | ND | ND |
a ND, not detected. b Different letters indicate a significant difference between groups (p < 0.05). Data were determined at 1 to 11 dpi. c Fecal consistency was scored as follows: 0, solid, 1, pasty, 2, semiliquid; and 3, liquid. Score of ≥ 2 was considered diarrhea. d Mean value = (sum of fecal consistency scores for each piglet)/N, where N is the number of surviving piglets in the period. Scores were calculated for piglets at 1 to 5, 7, 9, and 11 dpi. e The detection limit of RT-qPCR is 4.8 log10 GE/mL. f Not enough data to calculate standard deviation.