Table 4.
Multivariable adjusted associations of the CaScore with (death-censored) graft failure, death with a functioning graft and graft function decline.
| Outcomes Measures | Low CaScore | High CaScore | ||
|---|---|---|---|---|
| Hazard Ratio | Hazard Ratio | 95% CI | p-Value | |
| Death censored graft failure | ||||
| Univariate | 1.0 (Ref) | 1.5 | 0.9 to 2.5 | 0.125 |
| Model 1 | 1.0 (Ref) | 1.6 | 0.9 to 2.7 | 0.082 |
| Model 2 | 1.0 (Ref) | 1.4 | 0.8 to 2.4 | 0.211 |
| Model 3 | 1.0 (Ref) | 1.1 | 0.6 to 2.0 | 0.697 |
| Model 4 | 1.0 (Ref) | 1.1 | 0.6 to 2.0 | 0.711 |
| Overall graft failure | ||||
| Univariate | 1.0 (Ref) | 2.4 | 1.7 to 3.5 | <0.0001 |
| Model 1 | 1.0 (Ref) | 2.5 | 1.7 to 3.7 | <0.0001 |
| Model 2 | 1.0 (Ref) | 2.4 | 1.6 to 3.5 | <0.0001 |
| Model 3 | 1.0 (Ref) | 1.8 | 1.2 to 2.7 | 0.008 |
| Model 4 | 1.0 (Ref) | 1.9 | 1.2 to 2.9 | 0.006 |
| Death with a functioning graft | ||||
| Univariate | 1.0 (Ref) | 3.8 | 2.2 to 6.5 | <0.0001 |
| Model 1 | 1.0 (Ref) | 3.9 | 2.3 to 6.9 | <0.0001 |
| Model 2 | 1.0 (Ref) | 4.0 | 2.3 to 7.1 | <0.0001 |
| Model 3 | 1.0 (Ref) | 2.8 | 1.5 to 5.2 | 0.002 |
| Model 4 | 1.0 (Ref) | 2.7 | 1.4 to 5.0 | 0.004 |
| Graft function decline | ||||
| Univariate | 1.0 (Ref) | 1.6 | 1.0 to 2.6 | 0.038 |
| Model 1 | 1.0 (Ref) | 1.8 | 1.1 to 2.8 | 0.018 |
| Model 2 | 1.0 (Ref) | 1.6 | 1.0 to 2.6 | 0.043 |
| Model 3 | 1.0 (Ref) | 1.3 | 0.8 to 2.1 | 0.368 |
| Model 4 | 1.0 (Ref) | 1.4 | 0.8 to 2.4 | 0.223 |
Cox proportional hazards regression analysis. Data are presented as hazard ratio and 95% confidence interval (CI) for the two aorto-iliac CaScore groups (low and high). Model 1: adjusted for transplant centre and time between computed tomography and transplantation; model 2: adjusted for model 1 plus donor gender, donor type (living donation, donation after circulatory death (DCD), cold ischemia time, no. of human leukocyte antigen (HLA) mismatches, recipient gender, diabetes mellitus, dialysis vintage, and no. of previous transplantations, statin use; model 3: adjusted for model 2 plus recipient age; model 4: adjusted for model 3 plus donor age.